Effect of Early Normobaric Hyperoxia on Blast-Induced Traumatic Brain Injury in Rats.

Effect of Early Normobaric Hyperoxia on Blast-Induced Traumatic Brain Injury in Rats. Neurochem Res. 2020 Sep 09;: Authors: Li Y, Lv W, Cheng G, Wang S, Liu B, Zhao H, Wang H, Zhang L, Dong C, Zhang J Abstract Blast-induced traumatic brain injury (bTBI) is a leading cause of disability and mortality in soldiers during the conflicts in Iraq and Afghanistan. Although substantial clinical and animal studies have investigated the pathophysiology and treatments of bTBI, few effective therapies have been found, especially for the early rescue in the battlefield. The aim of this study is to evaluate neuroprotective effects of early normobaric hyperoxia (NBO) on bTBI. We established a rat model of bTBI caused by explosion in the cabin. It exhibited typical changes of mild bTBI, like impaired neurological function, brain edema, minor intracranial hemorrhage and neuron necrosis. The rats were divided into 4 groups (n = 12): Sham, Vehicle, hyperbaric oxygen (HBO) and NBO. Neurological function of the rats was assessed by the Neurological Severity Scores (NSS) at 24 h and 72 h after explosion. Serum interleukin-6 (IL-6), neuron specific enolase (NSE) and tau protein were measured at 24 h and 72 h after explosion. Brain water content was measured and Aquaporin-4 (AQP4) immunostaining was performed. Neuronal apoptosis was analyzed by TUNEL staining. NBO demonstrated curative effects on protecting the neurological function. Serum level...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research