Mitochondrial proteases and protein quality control in ageing and longevity.

Mitochondrial proteases and protein quality control in ageing and longevity.
Ageing Res Rev. 2015 Jan 8;
Authors: Hamon MP, Bulteau AL, Friguet B
Abstract
Mitochondria have been implicated in the ageing process and the lifespan modulation of model organisms. Mitochondria are the main providers of energy in eukaryotic cells but also represent both a major source of reactive oxygen species and targets for protein oxidative damage. Since protein damage can impair mitochondrial function, mitochondrial proteases are critically important for protein maintenance and elimination of oxidized protein. In the mitochondrial matrix, protein quality control is mainly achieved by the Lon and Clp proteases which are also key players in damaged mitochondrial proteins degradation. Accumulation of damaged macromolecules resulting from oxidative stress and failure of protein maintenance constitutes a hallmark of cellular and organismal ageing and is believed to participate to the age-related decline of cellular function. Hence, age-related impairment of mitochondrial protein quality control may therefore contribute to the age-associated build-up of oxidized protein and alterations of mitochondrial redox and protein homeostasis.
PMID: 25578288 [PubMed - as supplied by publisher]

Source: Ageing Research Reviews - January 8, 2015 Category: Genetics & Stem Cells Authors: Hamon MP, Bulteau AL, Friguet B Tags: Ageing Res Rev Source Type: research