Thread Size and Polymer Composition of 3D Printed and Electrospun Wound Dressings Affect Wound Healing Outcomes in an Excisional Wound Rat Model.

Thread Size and Polymer Composition of 3D Printed and Electrospun Wound Dressings Affect Wound Healing Outcomes in an Excisional Wound Rat Model.
Biomacromolecules. 2020 Sep 09;:
Authors: Nun N, Cruz M, Jain T, Tseng YM, Menefee J, Jatana S, Patil PS, Leipzig ND, McDonald C, Maytin E, Joy A
Abstract
Thread size and polymer composition are critical properties to consider for achieving a positive healing outcome with a wound dressing. 3D printed scaffolds and electrospun mats both offer distinct advantages as replaceable wound dressings. This research aims to determine if thread size and polymer compositions of scaffolds affect skin wound healing outcomes, an aspect that has not been adequately explored. Using a modular polymer platform, four polyester direct-write 3D printed scaffolds and electrospun mats were fabricated into wound dressings. The dressings were applied to splinted, full thickness skin wounds in an excisional wound rat model and evaluated against control wounds to which no dressing was applied. Wound closure rates and reduction of the wound bed width were not affected by thread size or polymer composition. However, epidermal thickness was larger in wounds treated with electrospun dressings and was slightly affected by polymer composition. Two of the four tested polymer compositions lead to delayed reorganization of granulation tissue. Moreover, enhanced angiogenesis was seen in wounds treated with 3D printed dressings ...

Source: Biomacromolecules - September 8, 2020 Category: Biochemistry Authors: Nun N, Cruz M, Jain T, Tseng YM, Menefee J, Jatana S, Patil PS, Leipzig ND, McDonald C, Maytin E, Joy A Tags: Biomacromolecules Source Type: research