Circulating RNA differences between patients with stable and progressive idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterised by progressive decline in pulmonary function. The rate of decline can vary, with some patients remaining stable over longer periods of time and others rapidly progressing [1]. The variable progression of this disease makes it difficult to elucidate pathogenic pathways involved in the initiation and progression of IPF. Advances in high-throughput gene-expression analyses have led to improvements in our understanding of disease biology and prognostic gene signatures. We hypothesise that IPF has a unique circulatory transcriptional profile compared to healthy controls, with additional differences between stable and progressive disease likely related to disease pathogenesis.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Clynick, B., Jo, H. E., Corte, T. J., Glaspole, I. N., Grainge, C., Hopkins, P. M. A., Reynolds, P. N., Chapman, S., Walters, E. H., Zappala, C., Keir, G. J., Cooper, W. A., Mahar, A. M., Ellis, S., Goh, N. S., Baltic, S., Ryan, M., Tan, D. B. A., Moodley Tags: Original Articles: Research letters Source Type: research