Does the Incorporation of Chemotherapy to Adjuvant Radiation Skew the Influence of Treatment Package Time in High-risk Oral Cavity Carcinoma? A Multi-institutional Collaborative Study
Treatment package time (TPT) defined as days elapsing from surgery to the end of adjuvant radiation therapy (RT) is known to impact outcomes in head and neck cancer patients receiving adjuvant RT alone.
Conditions: p16INK4a Negative Oropharyngeal Squamous Cell Carcinoma; Stage III Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage III Laryngeal Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage III Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7; Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7; Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7; Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7; Stage IVA Hypopharyngeal Squ...
Opinion statementStandard-of-care treatment for the majority of patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN) is either upfront surgery followed by adjuvant treatment as indicated by intraoperative or pathologic findings or concurrent chemoradiation reserving surgical salvage for non-responsive disease. An attempt at upfront complete resection should be pursued if feasible in patients with oral cavity or paranasal sinus primary tumors. Given multimodality treatment paradigms, patients with locoregionally advanced SCCHN should be managed in a multidisciplinary setting. Modern rad...
ConclusionsCXPA is an uncommon, high-grade malignant tumor with highly aggressive biologic behavior. Its occurrence in such sites as the soft palate is rare and cause diagnostic difficulties. In this case, a benign pleomorphic adenoma became complicated because of lack of adequate management and the poor choices made by the patient. It underwent high-grade malignant changes and metastasized to various organs of the body, ultimately resulting in the death of the patient.
Conclusion: Postoperative IMRT of carcinoma buccal mucosa and alveolus resulted in the highest LC rate of all the treatment subgroups assessed hence should be generously recommended in such cases especially ones with unfavorable features such as close resection margin, nodal involvement, locally advanced tumor (>T1N0), or recurrent disease, respectively. Despite definitive IMRT, locoregional control in carcinoma buccal mucosa and alveolus remain unsatisfactory, comparable to that following definitive 3D-CRT.
Conclusions: Intensity-modulated radiation with helical tomotherapy achieved respectable locoregional control and overall survival, with acceptable toxicity, in head and neck cancer patients.Oncology
CONCLUSIONS: Intensity-modulated radiation with helical tomotherapy achieved respectable locoregional control and overall survival, with acceptable toxicity, in head and neck cancer patients. PMID: 29895020 [PubMed - as supplied by publisher]
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck regions and accounts for more than 90% of cancers in the oral cavity . Although recent advances in surgical techniques, radiation therapy, and anticancer agents have improved tumor regression in and the survival of OSCC patients, wider surgical resection and/or higher intensity radio/chemotherapy inevitably results in a number of disabilities in oral function and daily living. In OSCC patients, postoperative dysfunctions depend on the primary site of the tumor, the area of surgical resection, and/or intensity of chemo/radiotherapy.
CONCLUSION: Patients treated with cetuximab had more cutaneous toxicities, but oral toxicity was similar between groups. The different IMRT modalities did not induce different toxicity profiles. PMID: 27345843 [PubMed - as supplied by publisher]
More than 59,000 new cases of head and neck cancers are estimated for 2015 in the US alone, including 45,000 cases arising in the oral cavity and pharynx and 13,000 in the larynx, resulting each year in approximately 11,000 cancer-associated deaths (http://seer.cancer.gov/). Most head and neck malignancies are squamous cell carcinoma (HNSCC), which remain associated with a poor outcome , primarily due to local tumor recurrence and regional lymph node and distant metastasis, despite of considerable advances in multimodality therapy including surgery, radiation therapy and chemotherapy to control local disease .
This study describes the clinicopathological profile of HNC in our local setting and highlights the challenges in the management of this disease. Methods: This was a retrospective study of histopathologically confirmed cases of head and neck cancers treated at Bugando Medical Center between January 2009 and December 2013. Results: A total of 346 patients (M:F = 2.1:1) were studied representing 9.5 % of all malignancies. The median age of patients was 42 years. Cigarette smoking (76.6 %) and heavy alcohol consumption (69.9 %) were the most frequently identified risk factors for head and neck ca...