Dose-Response Model for Severe Late Laryngeal Toxicity after Stereotactic Body Radiation Therapy for Previously Irradiated Head and Neck Cancer

Prior studies have demonstrated elevated risk of late grade ≥3 toxicity following stereotactic body radiation therapy (SBRT) for re-irradiation of recurrent head and neck cancer (rHNC) affecting the larynx or hypopharynx. Laryngeal toxicity, which can manifest as dysphagia, aspiration, laryngeal edema, or laryngeal stenosis, is one of the most commonly rep orted toxicities after SBRT for rHNC. At this time, no validated dose-volume constraints for the larynx exist to guide SBRT treatment planning.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research