Adjuvant Vaginal Cuff HDR Brachytherapy Prescribed to an Active Length of Two Centimeters Using Suspender Immobilization: A Baylor Scott & White Experience

Following hysterectomy for endometrial and cervical cancer, recurrence is common in the vaginal cuff. The American Brachytherapy Society recommends prescribing to an active length (AL) of 3-5 cm (AL) with vaginal cuff brachytherapy (VCB) following hysterectomy (Gaffney D, et al. Brachytherapy 2012). The most common fixed and fractional length prescriptions in endometrial cancer are 4 cm or the proximal half of the vagina, respectively (Small W Jr, et al. Brachytherapy 2016). Length of vagina irradiation is associated with toxicity (Smeds AC et al.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research

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Over the last years, increasing evidence has focused on crucial pathogenetic role of PRL on malignant, premalignant and benign uterine diseases. Studies in animals and humans have documented that PRL receptors (PRL-Rs) are widely expressed on uterine cells and that PRL is directly synthesized by the endometrium under the stimulatory action of progesterone. Uterine PRL secretion is finely modulated by autocrine/paracrine mechanisms which do not depend on the same control factors implied in the regulation of PRL secretion from pituitary. On the other hand, PRL is synthesized also in the myometrium and directly promotes uteri...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
We investigated the correlation between glandular cells (GC) detected at preoperative cervical-smear and the histologic findings and oncologic outcomes in patients undergoing surgery for endometrial cancer (EC). We retrospectively analyzed data of all consecutive EC patients who underwent surgery between January 1, 1990 and December 31, 2012 with preoperative cervical smear performed within 3 mo from the EC diagnosis. Basic descriptive, logistic regression and artificial neural network analyses were used. Five-year disease-free survival and overall survival were assessed using Kaplan-Meier and Cox hazard models. The...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: PATHOLOGY OF THE CORPUS: ORIGINAL ARTICLES Source Type: research
Authors: Shi Y, He R, Yang Y, He Y, Shao K, Zhan L, Wei B Abstract Cervical, ovarian and endometrial cancer are the three most common types of malignant tumor and the leading causes of cancer‑associated death in women. Tumor debulking surgery followed by platinum and paclitaxel chemotherapy is the current treatment regime of choice. However, as a result of late diagnosis and chemoresistance, the survival rates of patients with advanced gynecological cancers remains unsatisfactory. Circular RNAs (circRNAs) are stable noncoding RNAs that are present in a wide variety of tissue and cell types. With the enhancement o...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
CONCLUSION: Our data shows that picking a lower threshold value for CA 125 level (16 IU/L) instead of 35 IU/L, could be more useful in type-1 endometrial carcinoma patients with negative prognostic factors. PMID: 32979897 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
This article summarizes the existing literature and discusses the emerging role of hybrid PET/MRI in gynecologic malignancies. Thus, far, the published literature on the applications of FDG PET/MRI shows that it can have a significant impact on patient management by improving the staging of the cancers compared with PET/CT, influencing clinical decision and treatment strategy. For disease restaging, current literature indicates that PET/MRI performs equivalently to PET/CT. There appears to be a mild-moderate inverse correlation between standard-uptake-value (SUV) and apparent-diffusion-coefficient (ADC) values, which could...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conditions:   Cervical Carcinoma;   Endometrial Carcinoma;   Endometriosis;   Pelvic Inflammatory Disease Interventions:   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Radiation: Radiation Therapy Sponsors:   Mayo Clinic;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: In real-world practice, pembrolizumab was feasible and effective in heavily treated recurrent gynecologic cancer patients with poor performance status who may not be eligible for enrollment in clinical trials. PMID: 32975058 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
Objective The aim of the study was to describe the incidence and correlates of atypical glandular cell (AGC) Pap tests in a low socioeconomic status, underserved population. Materials and Methods Medical records of patients with AGC Pap tests at a single institution were reviewed from January 2013 to August 2019. Baseline characteristics were extracted including age, body mass index, birth control, abnormal uterine bleeding, and human papillomavirus (HPV). All colposcopy and endometrial biopsies were classified into negative/low-risk (polyps, tubular metaplasia, microglandular hyperplasia, cervical intraepithelial neo...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Cervical Neoplasia Screening and Management Source Type: research
Conclusions Cervical stenosis in women developing cervical cancer can cause misleading sampling and false-negative HPV test results.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Cervical Neoplasia Screening and Management Source Type: research
Abstract Ephrins are ligands of Eph receptors (Ephs); both of which are sorted into two classes, A and B. There are five types of ephrin-As (ephrin-A1-5) and three types of ephrin-Bs (ephrin-B1-3). Also, there are ten types of EphAs (EphA1-10) and six types of EphBs (EphB1-6). Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis and vascular remodeling. Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this syste...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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