Novel antibiotics may be non-inferior, but are they becoming less effective? A systematic review.

Novel antibiotics may be non-inferior, but are they becoming less effective? A systematic review.
Antimicrob Agents Chemother. 2020 Sep 08;:
Authors: Bai AD, Komorowski AS, Lo CKL, Tandon P, Li X, Mokashi V, Cvetkovic A, Findlater A, Liang L, Loeb M, Mertz D, McMaster Infectious Diseases Fellow Research Group
Abstract
Novel antibiotics approved by non-inferiority trials may become less effective over time in two scenarios: the treatment effect in studies on novel antibiotics may be consistently worse than studies on older antibiotics; or when a decreasingly effective control arm is used in a series of non-inferiority trials. Our systematic review of 175 non-inferiority antibiotic trials found these scenarios to be rare.
PMID: 32900680 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - September 7, 2020 Category: Microbiology Authors: Bai AD, Komorowski AS, Lo CKL, Tandon P, Li X, Mokashi V, Cvetkovic A, Findlater A, Liang L, Loeb M, Mertz D, McMaster Infectious Diseases Fellow Research Group Tags: Antimicrob Agents Chemother Source Type: research