Eerdun Wurile protects neuron and promotes neurite outgrowth through regulation of apoptotic gene expression in PC-12 cells

Eerdun Wurile (EW) is one of the most widely used traditional Mongolian medicines for stroke recovery. Previous studies revealed that EW regulates brain gene expression in a rat model of middle cerebral artery occlusion (MCAO). However, the fraction of active components and the specific genes regulated by such fractions have not been elucidated clearly. The study shows that the extracts of E...
Source: Journal of Medicinal Plants Research - Category: Complementary Medicine Source Type: research

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ConclusionBased on available information on pathophysiology and treatment of FH-1 in pregnancy, recommendations for the rational management of FH-1 in pregnancy are provided.
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionCompared with euthyroid status, hypothyroid status has an independent predicting value for adverse cardiovascular events in AMI patients. Further investigations are required to illustrate whether treatment of thyroid dysfunction could improve the prognosis of AMI patients.
Source: Endocrine - Category: Endocrinology Source Type: research
The National Institute of Neurological Disorders and Stroke (NINDS) is committed to reducing the disproportionate burden of neurological disease borne by underserved groups of society, including race/ethnic, sex/gender minorities, rural, disabled and socioeconomically disadvantaged populations, by funding a spectrum of research from basic through implementation science, and training the next generation of health disparities investigators. In 2020, the NINDS Office of Global Health and Health Disparities within the Division of Clinical Research, in collaboration with the Office of Science Policy and Planning, embarked on ...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
The National Institute of Neurological Disorders and Stroke (NINDS) is committed to reducing the disproportionate burden of neurological disease borne by underserved groups of society, including race/ethnic, sex/gender minorities, rural, disabled and socioeconomically disadvantaged populations, by funding a spectrum of research from basic through implementation science, and training the next generation of health disparities investigators. In 2020, the NINDS Office of Global Health and Health Disparities within the Division of Clinical Research, in collaboration with the Office of Science Policy and Planning, embarked on ...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
New data from MR CLEAN-MED show that aspirin and heparin, alone or in combination, double the risk for symptomatic intracranial hemorrhage when given during endovascular therapy (EVT) for ischemic stroke.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Aging has comparatively simple root causes, forms of cell and tissue damage that accumulate as a side-effect of the normal operation of metabolism. These comparatively simple causes take effect on a very, very complex system, however. The result is an intricate web of interacting consequences, and ultimately a dysfunctional, failing mess in which it is very hard to pinpoint which of the countless observed mechanisms are actually important. The complexity of the outcome is a result of the complexity of a living organism, not of the complexity of the root causes of aging. Metabolism is incompletely understood, and for so lon...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
In conclusion, medicarpin suppressed OGD/R-induced injury in HCMECs by activating PI3K/Akt/FoxO pathway.PMID:34523056 | DOI:10.1007/s11064-021-03449-0
Source: Cell Research - Category: Cytology Authors: Source Type: research
This study aims to evaluate the potential effects of rFGF21 on cerebrovascular remodeling after T2DM stroke. Permanent distal middle cerebral artery occlusion was performed in heterozygous non-diabetic db/ + and homozygous diabetic db/db mice. Daily rFGF21 administration was initiated 1 week after stroke induction and maintained for up to 2 weeks thereafter. Multiple markers associated with post-stroke recovery, including angiogenesis, oligodendrogenesis, white matter integrity, and neurogenesis, were assessed up to 3 weeks after stroke. Our results showed an impairment in post-stroke vascular remodeling under T2DM conditi...
Source: Cell Research - Category: Cytology Authors: Source Type: research
J Inflamm Res. 2021 Sep 7;14:4467-4483. doi: 10.2147/JIR.S327291. eCollection 2021.ABSTRACTAs a crucial kind of pervasive gene, long noncoding RNAs (lncRNAs) are abundant and key players in brain function as well as numerous neurological disorders, especially ischemic stroke. The mechanisms underlying ischemic stroke include angiogenesis, autophagy, apoptosis, cell death, and neuroinflammation. Inflammation plays a vital role in the pathological process of ischemic stroke, and systemic inflammation affects the patient's prognosis. Although a great deal of research has illustrated that various lncRNAs are closely relevant t...
Source: Cell Research - Category: Cytology Authors: Source Type: research
CONCLUSION: This study presents that depleting SOX2 improves IS via PVT1/miR-24-3p/STAT3 axis which may broaden our knowledge about the mechanisms of SOX2/PVT1/miR-24-3p/STAT3 axis and provide a reference of therapy for IS.PMID:34521353 | DOI:10.1186/s10020-021-00346-8
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
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