CaMKII Oxidation Regulates Cockroach Allergen-Induced Mitophagy in Asthma

Capsule summaryAllergen-induced excessive activation of autophagy in airway epithelium leads to increased ROS generation and release of pathogenic cytokines through oxidized CaMKII that may contribute to the development of Th2-associated allergic airway inflammation and asthma.

Source: Journal of Allergy and Clinical Immunology - September 9, 2020 Category: Allergy & Immunology Authors: Yan Zhang, Danh C. Do, Xinyue Hu, Ji Wang, Yilin Zhao, Sumita Mishra, Xin Zhang, Mei Wan, Peisong Gao Source Type: research