Macrophage-derived Wnt signaling increases endothelial permeability during skeletal muscle injury

ConclusionOur results indicate that macrophage-derived Wnt signaling increases endothelial permeability in a VEGF-dependent fashion following muscle injury. Our findings implicate macrophages as a primary source of Wnt ligands following muscle injury and highlight the Wnt pathway as a therapeutic target following injury.

http://link.springer.com/10.1007/s00011-020-01397-z

Source: Inflammation Research - September 8, 2020 Category: Research Source Type: research

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