Coronary Involvement in Cardiac Neonatal Lupus

A male infant, born to a mother who was receiving hydroxychloroquine because of Systemic Lupus Erythematosus, tested positive for autoantibodies anti-SSA/Ro. His laboratory tests revealed thrombocytopenia and elevated liver enzymes; antinuclear antibodies were positive (1:160), and strongly positive for anti-SSA/Ro and anti-histone antibodies. These findings were consistent with neonatal lupus erythematosus. Echocardiography showed striking and uniform coronary artery dilatations, with right coronary artery (RCA) cross-sectional diameter being 2 mm (Z-score 3.5), Left Main Coronary Artery (LMCA) 2 mm (Z-score 2.8) and Left Anterior Descending artery (LAD) 2 mm (Z-score 4.0) (Figure, A and B; Video 1 and Video 2 [available at www.jpeds.com]).
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Insights and Images Source Type: research