Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties.

Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties. J Zhejiang Univ Sci B. 2020 Sept.;21(9):745-748 Authors: Looi ML, Wong AKH, Gnapragasan SA, Japri AZ, Rajedadram A, Pin KY Abstract Piper betle (PB), also known as "betel" in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as eugenol and hydroxychavicol along with chlorophyll, β-carotene, and vitamin C (Salehi et al., 2019). Extracts from PB leaves have various medicinal properties including anticancer, antioxidant, anti-inflammatory, and antibacterial effects (Salehi et al., 2019). Previous research has shown that PB induces cell cycle arrest at late S or G2/M phase and causes apoptosis at higher doses (Wu et al., 2014; Guha Majumdar and Subramanian, 2019). A combination of PB leaf extract has also been shown to enhance the cytotoxicity of the anticancer drug, 5-fluorouracil (5-FU), in cancer cells (Ng et al., 2014). PMID: 32893531 [PubMed - in process]
Source: J Zhejiang Univ Sci ... - Category: Science Authors: Tags: J Zhejiang Univ Sci B Source Type: research