Concise asymmetric synthesis of new enantiomeric C-alkyl pyrrolidines acting as pharmacological chaperones against Gaucher disease

Org. Biomol. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0OB01522A, PaperTessa Castellan, Virginie Garcia, Fr édéric Rodriguez, Isabelle Fabing, Yevhenii Shchukin, My Lan Tran, Stephanie Ballereau, Thierry Levade, Yves Génisson, Cécile Dehoux-Baudoin A concise and asymmetric synthesis of the enantiomeric pyrrolidines 2 and ent-2 are herein reported. Both enantiomers were assessed as β-GCase inhibitors. While compound ent-2 acted as a poor competitive... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research