Hepatic insulin-degrading enzyme regulates glucose and insulin homeostasis in diet-induced obese mice

The insulin-degrading enzyme (IDE) is a metalloendopeptidase with a high affinity for insulin. Human genetic polymorphisms in Ide have been linked to increased risk for T2DM. In mice, hepatic Ide ablation causes glucose intolerance and insulin resistance when mice are fed a regular diet.

Source: Metabolism - Clinical and Experimental - September 7, 2020 Category: Biomedical Science Authors: Beatriz Merino, Cristina M. Fern ández-Díaz, Cristina Parrado-Fernández, Carlos M. González-Casimiro, Tamara Postigo-Casado, Carmen D. Lobatón, Malcolm A. Leissring, Irene Cózar-Castellano, Germán Perdomo Source Type: research