A noncanonical role of NOD-like receptor NLRP14 in PGCLC differentiation and spermatogenesis [Developmental Biology]

NOD-like receptors (NLRs) are traditionally recognized as major inflammasome components. The role of NLRs in germ cell differentiation and reproduction is not known. Here, we identified the gonad-specific Nlrp14 as a pivotal regulator in primordial germ cell-like cell (PGCLC) differentiation in vitro. Physiologically, knock out of Nlrp14 resulted in reproductive...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Yike Yin, Shiyu Cao, Huancheng Fu, Xueying Fan, Jingfei Xiong, Qiuyue Huang, Yu Liu, Kun Xie, Tie-Gang Meng, Yuliang Liu, Dan Tang, Tingting Yang, Biao Dong, Shiqian Qi, Ling Nie, Huiyuan Zhang, Hongbo Hu, Wenming Xu, Fuping Li, Lunzhi Dai, Qing-Yuan Sun, Tags: Biological Sciences Source Type: research