Transcriptome-wide analysis of PGC-1{alpha}-binding RNAs identifies genes linked to glucagon metabolic action [Cell Biology]

The peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a transcriptional coactivator that controls expression of metabolic/energetic genes, programming cellular responses to nutrient and environmental adaptations such as fasting, cold, or exercise. Unlike other coactivators, PGC-1α contains protein domains involved in RNA regulation such as serine/arginine (SR) and RNA recognition...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Clint D. J. Tavares, Stefan Aigner, Kfir Sharabi, Shashank Sathe, Beste Mutlu, Gene W. Yeo, Pere Puigserver Tags: Biological Sciences Source Type: research