Structural cavities are critical to balancing stability and activity of a membrane-integral enzyme [Biophysics and Computational Biology]

Packing interaction is a critical driving force in the folding of helical membrane proteins. Despite the importance, packing defects (i.e., cavities including voids, pockets, and pores) are prevalent in membrane-integral enzymes, channels, transporters, and receptors, playing essential roles in function. Then, a question arises regarding how the two competing requirements,...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Ruiqiong Guo, Zixuan Cang, Jiaqi Yao, Miyeon Kim, Erin Deans, Guowei Wei, Seung-gu Kang, Heedeok Hong Tags: Biological Sciences Source Type: research