Sequence-independent recognition of the amyloid structural motif by GFP protein family [Biochemistry]

Cnidarian fluorescent protein (FP) derivatives such as GFP, mCherry, and mEOS2 have been widely used to monitor gene expression and protein localization through biological imaging because they are considered functionally inert. We demonstrate that FPs specifically bind amyloid fibrils formed from many natural peptides and proteins. FPs do not bind...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Sherry C. S. Xu, Josephine G. LoRicco, Anthony C. Bishop, Nathan A. James, Welby H. Huynh, Scott A. McCallum, Nadia R. Roan, George I. Makhatadze Tags: Biological Sciences Source Type: research