Calcium modulates the domain flexibility and function of an {alpha}-actinin similar to the ancestral {alpha}-actinin [Biochemistry]
The actin cytoskeleton, a dynamic network of actin filaments and associated F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2 (EhActn2) with features expected for the common...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Nikos Pinotsis, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius Kostan, Muhammad Bashir Khan, Claudia Schreiner, Anita Salmazo, Luciano Ciccarelli, Martin Puchinger, Eirini A. Gkougkoulia, Euripedes de Almeida Ribeiro Jr, Thomas C. Marlovits, Al Tags: Biological Sciences Source Type: research