Magnetic resonance imaging accurately tracks kidney pathology and heterogeneity in the transition from acute kidney injury to chronic kidney disease.

Acute kidney injury is common in hospitalized patients. Many of the patients who experience AKI develop chronic kidney disease. However, using clinically available tools it is difficult to predict who and when CKD will develop. CFE-MRI provides several measurements of functional glomeruli in preclinical studies. CFE-MRI has the potential to be translated to use in humans, to detect changes in the kidney following acute kidney injury and predict which patients may develop CKD. The next steps toward translation will include in vivo tracking of glomerular fate in preclinical models of AKI to CKD and assessing the toxicity of CF in repeated doses.

Source: Kidney International - September 7, 2020 Category: Urology & Nephrology Authors: Jennifer R. Charlton, Yanzhe Xu, Teresa Wu, Kim A. deRonde, Jillian L. Hughes, Shourik Dutta, Gavin T. Oxley, Aleksandra Cwiek, Helen P. Cathro, Nathan P. Charlton, Mark R. Conaway, Edwin J. Baldelomar, Neda Parvin, Kevin M. Bennett Tags: basic research Source Type: research