Real World Effectiveness of Benralizumab in Severe Eosinophilic Asthma.

Real World Effectiveness of Benralizumab in Severe Eosinophilic Asthma. Chest. 2020 Aug 31;: Authors: Kavanagh JE, Hearn AP, Dhariwal J, Gráinne d'Ancona, Douiri A, Roxas C, Fernandes M, Green L, Thomson L, Nanzer AM, Kent BD, Jackson DJ Abstract BACKGROUND: Benralizumab is an IL5-receptor monoclonal antibody licensed for the treatment of severe eosinophilic asthma (SEA). It has demonstrated efficacy in clinical trials in reducing asthma exacerbation rates and maintenance oral corticosteroids (mOCS). RESEARCH QUESTION: Our aim was to evaluate the real-world effectiveness of benralizumab and identify any baseline characteristics associated with response to therapy. STUDY DESIGN: &Methods: We assessed outcomes in all SEA patients commenced on benralizumab at our specialist centre. At each dosing visit, exacerbation history, mOCS dose, spirometry, Asthma Control Questionnaire (ACQ6) and mini-Asthma Quality of Life Questionnaire (mAQLQ) scores were recorded. Response to treatment was defined as a reduction of ≥50% in annualised exacerbation rate (AER) or in mOCS dose after 48 weeks of treatment. Super-response was defined as zero exacerbations and no mOCS for asthma. RESULTS: 130 patients were included in the analysis. At 48 weeks there was a 72.8% reduction in AER, from 4.92±3.35 in the year preceding biologic treatment to 1.34±1.71 (p
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research

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CONCLUSION: Tracheal lesions mimic the symptoms of airway obstruction caused by asthma and should be always be part of the differential diagnosis in young patients with no response to asthma treatment. PMID: 32991249 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Spirometry is the most common pulmonary function test (PFT) used to follow asthma patients. It is recommended to withhold short-acting β2-agonists (SABA) a few hours before pulmonary function testing and to withhold long-acting β2-agonists (LABA) for diagnosis purpose but not for the assessment of response to a current treatment [1]. In children with asthma, the addition of LABA to inhaled corticosteroids (ICS) has no clear clinical benefit, but it has proved to improve baseline forced expiratory volume in 1 s (FEV1) [2]. The maximal increase in FEV1 after a single dose of formoterol was measured 3 h af...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research
Conclusions: In our study, FEV1% and ACT score could predict exacerbations of asthma whereas FeNO could not. FeNO level correlated inversely with ACT score. FeNO level decreased with inhaled corticosteroid usage.
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
CONCLUSION: Understanding similarities and differences among the recommendations of the various professional bodies will aid in medical decision-making in managing asthma in the COVID-19 pandemic. Health professionals should also consider the individual needs, preferences and values of their patients and the unique characteristics of their local healthcare systems. PMID: 32779943 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Abstract BACKGROUND: Fraction exhaled nitric oxide (FeNO) is a non-invasive biomarker of type-2 asthma that can predict response to inhaled corticosteroid(ICS) therapy. Little is known regarding the magnitude of FeNO reduction following an oral corticosteroid(OCS) course and less is known whether there are differential responses based on race in children with mild-to-moderate asthma. OBJECTIVE: To assess the effect of a short course of OCS on FeNO in asthmatic children and to determine if the effect is influenced by race. METHODS: Children presenting with an acute asthma exacerbation, who had a FeNO meas...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Ann Allergy Asthma Immunol Source Type: research
Conclusion: Results suggest that HRV analysis could be useful for the continuous monitoring of ANS anomalies present in asthma, thus contributing to evaluate the evolution of the disease, which is especially challenging in young children. Significance: Noninvasive ANS assessment using HRV analysis could be useful in the continuous monitoring of asthma in children.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Short-acting β2-agonists (SABAs) are inseparable from asthma. The word "Ventolin" has not only entered common language, but it profoundly symbolises relief from breathing distress, quite similar to how "nitroglycerin" supposedly rescues the heart. After the Second World War, synthetic corticosteroids revolutionised asthma management and gained nobility once an inhaled formulation was available [1]. Intriguingly, despite the fact that chronic airway inflammation is inherent to the definition of asthma, as needed SABA was kept in guidelines as the preferred option for the mildest patients, and this u...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Editorials Source Type: research
n C Abstract The aim of this study was to identify asthma phenotypes through cluster analysis. Cluster analysis was performed using self-reported characteristics from a cohort of 1291 Swedish asthma patients. Disease burden was measured using the Asthma Control Test (ACT), the mini Asthma Quality of Life Questionnaire (mini-AQLQ), exacerbation frequency and asthma severity. Validation was performed in 748 individuals from the same geographical region. Three clusters; early onset predominantly female, adult onset predominantly female and adult onset predominantly male, were identified. Early onset predominantly fem...
Source: Primary Care - Category: Primary Care Authors: Tags: NPJ Prim Care Respir Med Source Type: research
kaanranta H Abstract Primary health care (PHC) providers are at the front line of asthma management. To evaluate how planned asthma follow-up occurred in PHC and whether lung function tests were used, 203 patients were followed for 12 years as part of a real-life asthma cohort Seinäjoki Adult Asthma Study (SAAS). A total of 152 patients had visits in PHC attending on average to four planned contacts during 12-year follow-up corresponding to one visit every third year. National guideline recommends annual visits. Patients with ≥4 contacts seemed to have more difficult asthma and better adherence to inhaled ...
Source: Primary Care - Category: Primary Care Authors: Tags: NPJ Prim Care Respir Med Source Type: research
ConclusionsThis large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
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