Cancers, Vol. 12, Pages 2554: Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer

In conclusion, the CSC-suppressive effect of metformin was associated with AMPK activation and repression of protein prenylation through MVA pathway suppression in colorectal cancer.

Source: Cancers - September 7, 2020 Category: Cancer & Oncology Authors: Yoojeong Seo Janghyun Kim Soo Jung Park Jae Jun Park Jae Hee Cheon Won Ho Kim Tae Il Kim Tags: Article Source Type: research