Prognostic significance for colorectal carcinoid tumors based on the 8th edition TNM staging system

For all carcinoid tumors, detailed 8th AJCC categories of advanced stages conferred increased HRs with overlapping CIs. However, in the early and middle status, HRs did not increase with the increase of stages, or there was no difference in HRs between adjacent stages. More optimized staging methods should be developed and validated in the future. AbstractThe aim of our study was to explore the value of the 8th edition TNM staging system on evaluating the prognosis of colorectal carcinoid. Colorectal carcinoid patients between 1988 and 2015 were selected in the Surveillance, Epidemiology, and End Results Program (SEER) database for analysis. About 4286 patients with colorectal carcinoid tumors were identified, of which were carcinoid tumor NOS (n  = 1726), neuroendocrine carcinoma (NEC) (n = 1346) and other carcinoid tumor (OCT) (n = 591). Worsening 10‐year CSS rates with increasing N status, M status, and SEER historic stage were demonstrated across all three above groups (allP <  .05). In carcinoid tumor NOS, significant differences in CSS were found with increasing combined 8th AJCC stages (P <  .001), except for that between stage II and stage III (10‐year CSS rate: 82.6% vs 84.3%,P = .68). While combined 8th TNM stage in NEC and OTC exhibited greater separations in CSS despite on‐going overlaps between groups. For carcinoid tumor NOS, stage II (HR = 3.37; 95% CI: 0.97‐11.76), and stage III (HR = 2.09; 95% CI: 0.51‐8.66) conferred no signif...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research