Obesity, COVID-19 and Innate Immunometabolism.

Obesity, COVID-19 and Innate Immunometabolism. Br J Nutr. 2020 Sep 07;:1-9 Authors: Gleeson LE, Roche HM, Sheedy FJ Abstract As COVID-19 continues to spread worldwide, severe disease and mortality has been observed in obese patients. We discuss how obesity and obesity-associated factors such as "meta-flammation", dietary fat intake, and paradoxical suppression of the innate immune response within the pulmonary compartment may be crucial determinants in the host response to a novel viral pathogen. Modulation of immune cell bioenergetics and metabolic potential plays a central role in the innate immune response to infection, and as we strive to combat this new global health threat, immunometabolism of the innate immune system warrants attention. PMID: 32892755 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - Category: Nutrition Authors: Tags: Br J Nutr Source Type: research