Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability

Maintaining the integrity of blood-brain barrier (BBB) is one of the most important factors for brain homeostasis and cell survival during cerebral ischemic-reperfusion. Decreasing BBB disruption has been associated with better neuronal outcome in cerebral ischemia-reperfusion.1 –3 It is critical to find agents or regimen that can decrease the degree of the BBB disruption associated with cerebral ischemia especially during the very early stage of reperfusion.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research