Cryo-EM as a powerful tool for drug discovery.

Cryo-EM as a powerful tool for drug discovery.
Bioorg Med Chem Lett. 2020 Sep 02;:127524
Authors: Van Drie JH, Tong L
Abstract
The recent revolution in cryo-EM has produced an explosion of structures at near-atomic or better resolution. This has allowed cryo-EM structures to provide visualization of bound small-molecule ligands in the macromolecules, and these new structures have provided unprecedented insights into the molecular mechanisms of complex biochemical processes. They have also had a profound impact on drug discovery, defining the binding modes and mechanisms of action of well-known drugs as well as driving the design and development of new compounds. This review will summarize and highlight some of these structures. Most excitingly, the latest cryo-EM technology has produced structures at 1.2 Å resolution, further solidifying cryo-EM as a powerful tool for drug discovery. Therefore, cryo-EM will play an ever-increasing role in drug discovery in the coming years.
PMID: 32890683 [PubMed - as supplied by publisher]

Source: Bioorganic and Medicinal Chemistry Letters - September 1, 2020 Category: Chemistry Authors: Van Drie JH, Tong L Tags: Bioorg Med Chem Lett Source Type: research