Promoting Physical Activity in Older Adults With Knee Osteoarthritis and Hypertension: A Randomized Controlled Trial.

Promoting Physical Activity in Older Adults With Knee Osteoarthritis and Hypertension: A Randomized Controlled Trial. J Aging Phys Act. 2020 Sep 04;:1-12 Authors: Schlenk EA, Fitzgerald GK, Rogers JC, Kwoh CK, Sereika SM Abstract A 6-month self-efficacy intervention was compared with attention-control intervention on physical activity, clinical outcomes, and mediators immediate postintervention and 6-month postintervention in 182 older adults with knee osteoarthritis and hypertension using a randomized controlled trial design. The intervention group received six weekly individual physical therapy sessions for lower-extremity exercise and fitness walking and nine biweekly nurse telephone counseling sessions. The attention-control group received six weekly and nine biweekly nurse telephone sessions on health topics. Lower-extremity exercise was assessed by e-diary; fitness walking was assessed by accelerometer and e-diary; blood pressure was assessed by automated monitor; function was assessed by performance-based tests and questionnaires; and pain, self-efficacy, and outcome expectancy were assessed by questionnaires. Self-reported lower-extremity exercise and fitness walking, function, pain, self-efficacy, and outcome expectancy showed significant group or group by time effects favoring intervention. The intervention did not improve physical activity by accelerometer and blood pressure. Mean minutes of fitness walking fell short of the 150 min/week g...
Source: Journal of Aging and Physical Activity - Category: Geriatrics Tags: J Aging Phys Act Source Type: research

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To examine the association of hypertension with knee pain severity in individuals with knee osteoarthritis (OA).
Source: Pain Management Nursing - Category: Nursing Authors: Tags: Original Research Source Type: research
CONCLUSION: MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1s. Nodal and erosive HOA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.PMID:34329188 | DOI:10.3899/jrheum.210189
Source: Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
CONCLUSION: MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1. Nodal and erosive OA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.PMID:34329188 | DOI:10.3899/jrheum.210189
Source: J Rheumatol - Category: Rheumatology Authors: Source Type: research
AbstractIntroductionOsteoarthritis (OA) is a major cause of physical impairment in older persons. Few studies have determined the relationship between the presence of OA and frailty. We evaluated the prospective relationship between knee pain and frailty in a Malaysian longitudinal cohort.MethodData from Malaysian Elders Longitudinal Research (MELoR) study were utilised. Baseline data were obtained from home-based computer-assisted questionnaires and hospital-based health-checks from 2013 –2015. The presence of knee pain was determined with the single question, ‘do you have pain in your knee(s)?’. Frailty...
Source: Age and Ageing - Category: Geriatrics Source Type: research
Expert Opin Pharmacother. 2021 May 3:1-5. doi: 10.1080/14656566.2021.1915289. Online ahead of print.ABSTRACTIntroduction: A fixed-dose combination of amlodipine and celecoxib, branded in the USA as Consensi®, was recently granted a US Food and Drug Administration (FDA)-approved indication for treatment of comorbid hypertension and osteoarthritis.Areas covered: A PubMed and Medline search was conducted for clinical trials published through December 2020 in the English language using keywords amlodipine, celecoxib, combination product, consensi, hypertension, osteoarthritis, and pill burden. Although no clinical trials h...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Authors: Source Type: research
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders. Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPatients with cancer often exhibit multiple co ‐occurring symptoms which can impact the type of treatment received, recovery, and long‐term health. We aim to simultaneously predict the risk of three symptoms: severe pain, moderate‐severe depression, and poor well‐being in order to flag patients who may benefit from pre‐emptive early sy mptom management. This was a retrospective population‐based cohort study of adults diagnosed with cancer between 2008 and 2015. We developed and tested an Artificial Neural Network (ANN) model to predict the risk of multiple co‐occurring symptoms within 6 months af...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionIn Japanese patients with OA and CLBP, we saw a trend of increased risk for AMI in patients using NSAIDs for more than 5  years. Elderly patients had a higher prevalence of diabetes, hypertension, and other CVD which increased the risk of AMI. Although NSAID patches were preferred to oral NSAIDs in elderly patients, risk for AMI was similar between the two modalities. Therefore, we suggest using NSAIDs carefully, esp ecially in elderly patients and those at risk of developing CVD.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
  Sarah’s story reminds us how the simple matter of diet can shape our lives for decades, affecting energy, body weight, emotional health–just about every aspect of our physical and social lives before we finally stumble on the right answers. After many years of struggling with poor health, relying on prescription medications that never addressed underlying causes, it therefore came as a surprise to Sarah that she could indeed achieve magnificent health without the drugs by simply following the diet programmed into human genetic code and supplementing nutrients that are deficient in modern life.   &ld...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open grain-free Inflammation joint pain wheat belly Source Type: blogs
AbstractIntroductionNonsteroidal anti-inflammatory drugs (NSAIDs) have long-term benefits but are limited by side effects. We assessed the health and economic burden of renal events associated with NSAID use in patients with osteoarthritis (OA) and/or chronic low back pain (CLBP).MethodsThis retrospective, large-scale, medical claims database study of Japanese patients receiving NSAIDs for OA and/or CLBP between 2009 and 2018 assessed the incidence of renal events and effect of treatment duration, mode of administration, and usage consistency of NSAIDs.ResultsOf 180,371 patients, NSAIDs were prescribed as first-line analge...
Source: Pain and Therapy - Category: Anesthesiology Source Type: research
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