EP News Clinical September 2020

Knopps et al (N Engl J Med 2020;383(6):526-536. PMID: 32757521) conducted a noninferiority trial in patients with an indication for an ICD but no indication for pacing. Patients (849) were randomized to receive a subcutaneous ICD (S-ICD, 426) or transvenous ICD (T-ICD,423). The primary end point was the composite of device-related complications and inappropriate shocks. Secondary end points included death and appropriate shocks. Over 49.1 months, a primary end-point event occurred in 68 S-ICD patients and 68 T-ICD patients (48-month incidence, 15.1% and 15.7%, respectively; HR, 0.99; P = 0.01 for noninferiority; P = 0.95 for superiority).

Source: Heart Rhythm - September 6, 2020 Category: Cardiology Authors: N. A. Mark Estes Source Type: research