Melatonin treatment of repetitive behavioral deficits in the Cntnap2 mouse model of autism spectrum disorder.
In this study, we examined the impact of exposure to dim light at night (DLaN, 5 lx) in a model of ASD: the contactin associated protein-like 2 knock out (Cntnap2 KO) mice. DLaN was sufficient to disrupt locomotor activity rhythms, exacerbate the excessive grooming and diminish the social preference in Cntnap2 mutant mice. On a molecular level, DLaN altered the phase and amplitude of PER2::LUC rhythms in a tissue-specific manner in vitro. Daily treatment with melatonin reduced the excessive grooming of the mutant mice to wild-type levels and improved activity rhythms. Our findings suggest that common circadian disruptors such as light at night should be considered in the management of ASD. PMID: 32889171 [PubMed - as supplied by publisher]
MONDAY, Oct. 5, 2020 -- Developmental and behavioral functioning often associated with children diagnosed with autism spectrum disorder (ASD), such as sensory sensitivity, aggression, and sleep disorders, may be linked to a nonverbal manifestation...
Abstract Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific differences in the clinical profile have been observed in FXS patients, but few studies have directly compared males and females in rodent models of FXS. To address this, we performed electroencephalography (EEG) recordings and a battery of autism-related behavioral tasks on juvenile and young adult Fmr1 knockout (KO) rats. EEG analysis demonstrated that compared to wild-type, male Fmr1 KO rats showed an increase in gamma frequency band power in th...
CONCLUSION: Further are required for understanding the relationship between melatonin, circadian rhythm and ASD, which will not only shed light on the role of melatonin in the etiology of ASD, but may also guide to early intervention options. PMID: 32978956 [PubMed - in process]
ConclusionThis case report provides evidence that a lower than previously reported dose of a phytocannabinoid in the form of a cannabidiol-based extract may be capable of aiding in autism spectrum disorder-related behavioral symptoms, core social communication abilities, and comorbid anxiety, sleep difficulties, and weight control. Further research is needed to elucidate the clinical role and underlying biological mechanisms of action of cannabidiol-based extract in patients with autism spectrum disorder.
If you find yourself wondering if everything will go wrong in 2020, you are far from alone. This year has seen more than its share of heartache, and it isn’t over yet. Help may never arrive — how can you keep going? It’s challenging to stay strong when everything seems to be going wrong. While the tips below are no substitute for professional care, financial and other circumstances don’t always make seeking treatment an option. These 10 self-care practices may keep you from capsizing when the seas grow rocky. 1. Take a Deep Breath Many times, you grow anxious from future fears, not fr...
Conditions: Insomnia Chronic; Autism Spectrum Disorder Interventions: Behavioral: In-Person CBT for insomnia in children with autism; Behavioral: Remote CBT for insomnia in children with autism; Behavioral: Remote sleep hygiene and related education (SHARE) for insomnia in children with autism Sponsors: University of Missouri-Columbia; United States Department of Defense Not yet recruiting
Conditions: Autism; Autism Spectrum Disorder; Sleep Intervention: Behavioral: Behavioral treatment for sleep difficulties Sponsor: Soroka University Medical Center Not yet recruiting