In utero alcohol exposure exacerbates endothelial protease activity from pial microvessels and impairs GABA interneuron positioning.

This study provides the first mechanistic and functional evidence that alcohol impairs glutamate-regulated activity of pial microvessels. Endothelial dysfunction is characterized by altered metalloproteinase activity and interneuron mispositioning, which was also observed in a fetus with fetal alcohol syndrome. These data suggest that alcohol-induced endothelial dysfunction may contribute in ectopic cortical GABAergic interneurons, that has previously been described in infants with FASD.
PMID: 32890773 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - September 1, 2020 Category: Neurology Authors: Léger C, Dupré N, Laquerrière A, Lecointre M, Dumanoir M, Janin F, Hauchecorne M, Fabre M, Jégou S, Frébourg T, Cleren C, Leroux P, Marcorelles P, Brasse-Lagnel C, Marret S, Marguet F, Gonzalez BJ Tags: Neurobiol Dis Source Type: research