The role of the comprehensive complication index for the prediction of survival after liver transplantation

This study aims to evaluate the role of the comprehensive complication index (CCI) as a useful scoring system for accurately predicting 90-day and 1-year graft loss after liver transplantation. A training set (n = 1262) and a validation set (n = 520) were obtained. The study was registered athttps://www.ClinicalTrials.gov (ID: NCT03723317). CCI exhibited the best diagnostic performance for 90  days in the training (AUC = 0.94;p <  0.001) and Validation Sets (AUC = 0.77;p <  0.001) when compared to the BAR, D-MELD, MELD, and EAD scores. The cut-off value of 47.3 (third quartile) showed a diagnostic odds ratio of 48.3 and 7.0 in the two sets, respectively. As for 1-year graft loss, CCI showed good performances in the training (AUC = 0.88;p <  0.001) and validation sets (AUC = 0.75;p <  0.001). The threshold of 47.3 showed a diagnostic odds ratio of 21.0 and 5.4 in the two sets, respectively. All the other tested scores always showed AUCs <  0.70 in both the sets. CCI showed a good stratification ability in terms of graft loss rates in both the sets (log-rankp <  0.001). In the patients exceeding the CCI ninth decile, 1-year graft survival rates were only 0.7% and 23.1% in training and validation sets, respectively. CCI shows a very good diagnostic power for 90-day and 1-year graft loss in different sets of patients, indicating better accuracy with respec t to other pre- and post-LT scores.Clinical Trial Notifica...
Source: Updates in Surgery - Category: Surgery Source Type: research