Effect of ABCB1 3435C > T Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult Renal Transplant Recipients: a Systematic Review and Meta-analysis.
Effect of ABCB1 3435C>T Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult Renal Transplant Recipients: a Systematic Review and Meta-analysis.
Clin Ther. 2020 Sep 01;:
Authors: Peng W, Lin Y, Zhang H, Meng K
Abstract
PURPOSE: Tacrolimus is the substrate of multidrug-resistance 1 (ABCB1). However, the effect of ABCB1 C3435T polymorphism on pharmacokinetic variables of tacrolimus is controversial in different studies. This meta-analysis was conducted to explore the relationship between ABCB1 3435C>T genetic polymorphism and pharmacokinetic variables of tacrolimus.
METHODS: A database search was conducted of PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov, as well as Chinese databases (SinoMed, Wan Fang, and China National Knowledge Infrastructure). We also scanned reference lists and corresponded with authors. The study explored the relationship between ABCB1 3435C>T genetic polymorphism and pharmacokinetic variables of tacrolimus stratified according to time of posttransplantation, ethnicity, methods of concentration measurement, and the initial doses of tacrolimus.
FINDINGS: Sixteen studies were included in this meta-analysis. In the subgroup analysis, ABCB1 3435TT had a significantly lower weight-adjusted dose than ABCB1 3435CC, which was not observed in the ABCB1 3435CT group. The subgroup analysis then revealed that the tacrolimus concentration/weight-adjusted daily dose rati...
Source: Clinical Therapeutics - Category: Drugs & Pharmacology Authors: Peng W, Lin Y, Zhang H, Meng K Tags: Clin Ther Source Type: research
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