Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population.

CONCLUSION: Germline pathogenic TP53 variants were found in 4% early-onset Polish BC patients. No founder mutations were identified in Polish population. To improve the treatment and surveillance screening, the search for germline TP53 pathogenic variants is recommended for all female BC cases diagnosed ≤ 30 years old. PMID: 32888145 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32888145?dopt=Abstract

Source: Breast Cancer - September 3, 2020 Category: Cancer & Oncology Authors: Rogoża-Janiszewska E, Malińska K, Górski B, Scott RJ, Cybulski C, Kluźniak W, Lener M, Jakubowska A, Gronwald J, Huzarski T, Lubiński J, Dębniak T Tags: Breast Cancer Source Type: research