Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.

In conclusion, 900 mg of isoniazid, administered twice a week, did not effectively prevent QFT conversion at a cutoff point ≥ 0.35 IU/mL in a trial of QFT-negative inmates. Higher QFT cutoffs are associated with sustained conversion and greater protection. Future clinical trials that evaluate protection for latent infection should use the highest cutoff than that recommended by the manufacturer.
PMID: 32876010 [PubMed - as supplied by publisher]

Source: The American Journal of Tropical Medicine and Hygiene - August 30, 2020 Category: Tropical Medicine Authors: Dias de Oliveira R, da Silva Santos A, Reis CB, de Cássia Leite A, Correia Sacchi FP, Araujo RP, Dos Santos PP, Rolla VC, Martinez L, Andrews J, Croda J Tags: Am J Trop Med Hyg Source Type: research