Deciphering the role of aberrant protein post translational modification in the pathology of neurodegeneration.

Deciphering the role of aberrant protein post translational modification in the pathology of neurodegeneration. CNS Neurol Disord Drug Targets. 2020 Sep 03;: Authors: Shafi S, Singh A, Gupta P, Chawla PA, Fayaz F, Sharma A, Pottoo FH Abstract Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD), are characterized by progressive neuronal dysfunction and death. Current studies have established detrimental modifications in brain protein function as well as structure which stimulate their aggregation, misfolding and deposition in and around the neurons, as an important hallmark of neurodegenerative disorders. Posttranslational modification (PTM) of proteins including phosphorylation, acetylation, glycosylation, palmitoylation, SUMOylation, and ubiquitination are important regulators of protein characteristics including stability, intracellular distribution, activity, interactions, aggregation and clearance. Despite clear evidence that altered protein modifications emerging from impromptu chemical modifications to side chains of amino acid is associated with neurodegeneration, the underlying mechanisms that promote aberrant PTM remain poorly understood. Therefore, elucidating PTM of specific disease associated proteins can prove to be a significant step in evaluating functional alteration of proteins and their association with neurodege...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research