Macrophage polarization in peri-implantitis lesions

ConclusionThe present immunohistochemical analysis suggests that macrophages constitute a considerable proportion of the inflammatory cellular composition at peri-implantitis sites, revealing a significant higher expression for M1 inflammatory phenotype at advanced peri-implantitis sites, which could possibly play a critical role in disease progression.Clinical relevanceMacrophages have critical functions to establish homeostasis and disease. Bacteria might induce oral dysbiosis unbalancing the host ’s immunological response and triggering inflammation around dental implants. M1/M2 status could possibly reveal peri-implantitis’ underlying pathogenesis.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research