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Detectable serum allergen-specific IgE is present without the development of allergy for unclear reasons and is responsible for up to 50% false positive rates in diagnosis of peanut allergy. Because the post-translational modification glycosylation is established to modulate the effector function of IgG, Shade et al (Nature 2020;582:265-70. https://doi.org/10.1038/s41586-020-2311-z) characterized the glycosylation patterns of serum IgE from peanut-allergic individuals and nonatopic controls. IgE from peanut-allergic individuals exhibited increased levels of sialic acid, and removal of sialic acid from IgE decreased its ability to activate mast cells and basophils and to induce experimental murine allergy.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research