Descriptive analysis of low versus elevated intracranial pressure on cerebral physiology in adult traumatic brain injury: a CENTER-TBI exploratory study

ConclusionsLow versus high ICP during the first 72  h after moderate/severe TBI is associated with significant disparities in CPP, AMP, cerebrovascular reactivity, cerebral compensatory reserve, and brain tissue oxygenation metrics. Such ICP extremes appear to be strongly related to 6-month patient outcomes, in keeping with previous literature. Thi s work provides multi-center validation for previously described single-center retrospective results.
Source: Acta Neurochirurgica - Category: Neurosurgery Source Type: research