Joining Datasets Without Identifiers: Probabilistic Linkage of Virtual Pediatric Systems and PEDSnet*

Conclusions: We demonstrated the use of probabilistic linkage to accurately join two complementary pediatric critical care datasets at a single academic PICU in the absence of protected health information. Combining datasets with curated diagnoses and granular measurements can validate patient acuity metrics and facilitate multicenter machine learning algorithms. We anticipate these methods will generalize to other common PICU diagnoses.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

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Publication date: October 2020Source: Archives of Cardiovascular Diseases Supplements, Volume 12, Issues 2–4Author(s): A. Bangy-Letheule, F. Souab, S. Bourgoin, S. Michelland, V. Cunin, M. Seve, V. Aillerie, J. Dhot, J. Montnach, A. Persello, B. Rozec, B. Lauzier, M. De Waard
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Publication date: Available online 24 September 2020Source: Acta Pharmaceutica Sinica BAuthor(s): Zhilei Wang, Guang Xu, Yuan Gao, Xiaoyan Zhan, Nan Qin, Shubin Fu, Ruisheng Li, Ming Niu, Jiabo Wang, Youping Liu, Xiaohe Xiao, Zhaofang Bai
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Authors: Kurihara Y, Maruhashi T, Wada T, Osada M, Oi M, Yamaoka K, Asari Y Abstract Severe coronavirus disease (COVID-19) can induce serious complications, including acute respiratory distress syndrome, septic shock, and acute kidney injury. However, few reports have associated COVID-19 with pancreatitis. We herein report the case of a 55-year-old patient who developed acute pancreatitis associated with severe COVID-19 pneumonia and was successfully treated with veno-venous extracorporeal membrane oxygenation (ECMO). Elevated pancreatic enzymes levels and computed tomography findings led to the diagnosis of acute ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
An index combining respiratory rate and oxygenation (ROX) has been introduced, and the ROX index is defined as the ratio of oxygen saturation by pulse oximetry/fraction of inspired oxygen to respiratory rate. In sepsis, hypoxemia and tachypnea are commonly observed. We performed this study to investigate the association between the ROX index and 28-day mortality in patients with sepsis or septic shock.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Authors: Philips CA, Ahamed R, Rajesh S, George T, Mohanan M, Augustine P Abstract Sepsis and septic shock are catastrophic disease entities that portend high mortality in patients with cirrhosis. In cirrhosis, hemodynamic perturbations, immune dysregulation, and persistent systemic inflammation with altered gut microbiota in the background of portal hypertension enhance the risk of infections and resistance to antimicrobials. Patients with cirrhosis develop recurrent life-threatening infections that progress to multiple organ failure. The definition, pathophysiology, and treatment options for sepsis have been ever...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
Sepsis is not a monolithic disease, but a loose collection of symptoms with diverse outcomes. Thus, stratification and subtyping of sepsis patients is of great importance. We examine the temporal evolution of patient state using our previously-published method for computing risk of transition from sepsis into septic shock. Risk trajectories diverge into four clusters following early prediction of septic shock, stratifying by outcome: the highest-risk and lowest-risk groups have a 76.5% and 10.4% prevalence of septic shock, and 43% and 18% mortality, respectively. These clusters differ also in treatments received and median...
Source: eLife - Category: Biomedical Science Tags: Computational and Systems Biology Source Type: research
ConclusionIn this nested case –control study, we demonstrated a significant association between IAH and high-dose glucocorticoid with significant duration–response effects. Serum sodium concentrations should be monitored carefully in critically ill patients administered prolonged high-dose glucocorticoid.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Source: Critical Care - Category: Intensive Care Authors: Tags: Research Letter Source Type: research
Publication date: Available online 18 September 2020Source: Journal of Critical CareAuthor(s): Xiaoming Li, Chao Liu, Zhi Mao, Shuang Qi, Renjie Song, Feihu Zhou
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Publication date: Available online 17 September 2020Source: Journal of Critical CareAuthor(s): Brittany R. Kiracofe, Bruce A. Doepker, Heidi M. Riha, Rachel Wilkinson, Elizabeth Rozycki, Eric Adkins, Amy Lehman, Megan A. Van Berkel
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
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