A Multicenter, Retrospective, Case Series of Patients with Charcot Neuroarthropathy Deformities Undergoing Arthrodesis Utilizing Recombinant Human Platelet-Derived Growth Factor with Beta-Tricalcium Phosphate

Charcot neuroarthropathy has traditionally been treated using both non-surgical and surgical strategies. Recently, orthobiologics have been used to promote arthrodesis in Charcot reconstructions, obviating the need for bone graft in some cases. Recombinant human platelet-derived growth factor BB homodimer (rhPDGF-BB) in combination with beta-tricalcium phosphate scaffold ( β-TCP) is a bone graft substitute shown to have comparable efficacy to autograft in incidence of foot and ankle fusion. This multicenter, consecutive case series analyzed patients undergoing Charcot reconstructions utilizing rhPDGF-BB/β-TCP for joint fusion.
Source: Journal of Foot and Ankle Surgery - Category: Orthopaedics Authors: Source Type: research