Performance of a real-time PCR approach for diagnosing Schistosoma haematobium infections of different intensity in urine samples from Zanzibar

ConclusionsWhile the sensitivity of the qPCR was ~  80% for very light intensity infections (egg counts<  10), in general, theDra1 based qPCR assay detected twice as manyS. haematobium infections compared with classical parasitological tests. The qPCR is hence a sensitive, urine-based approach forS. haematobium diagnosis that can be used for impact assessment of schistosomiasis elimination programmes, individual diagnosis, and in improved format also for verification and certification of elimination.Trial registrationISRCTN,ISRCTN48837681. Registered 05 September 2012 - Retrospectively registered.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research