Study identifies how infection by Zika virus during pregnancy can affect the fetal brain

(Funda ç ã o de Amparo à Pesquisa do Estado de S ã o Paulo) The study by more than 30 Brazilian scientists investigated tens of thousands of genomic, transcriptomic and proteomic variables, discovering several alterations caused by the v í rus.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Zika virus (ZIKV) is an emerging arbovirus belonging to the genus Flavivirus, family Flaviviridae, which includes other viruses relevant to public health, such as dengue (DENV), yellow fever (YFV) and West Nile (WNV) viruses. Although ZIKV infection in humans is often characterized as a self-limiting disease 1,2, infections during pregnancy can lead to fetal malformations and neurodevelopment abnormalities 3 –5.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Conclusions: Results showed a low incidence of ZIKV-associated birth defects, stillbirth, and miscarriage, which contrasts with previous studies in other Brazilian regions. Previous exposure to yellow fever vaccine and/or multiserotype DENV infection could be implicated in the protection from ZIKV congenital infection. PMID: 32952536 [PubMed]
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
Background: The emergence of Zika virus (ZIKV) in the Americas has aroused global concern due to its unexpected ability to cause congenital diseases in the context of infection during pregnancy. Previously, we have demonstrated that a single amino acid substitution (S139N) in the prM protein of ZIKV enhances viral neurovirulence and contributes to fetal microcephaly. Yet, how ZIKV crosses the placental barrier to target the fetal brain remains largely unknown.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0520 Source Type: research
This study assessed the effects of pyriproxyfen on reproductive performance, embryo-fetal development, head measurements, and DNA integrity in a preclinical model. Thirty pregnant mice were divided into three groups (n = 10): control (drinking water-0.1 ml/10 g (body weight-b.w., gavage) and treated with pyriproxyfen 0.0002 mg/kg and 0.0021 mg/kg (b.w., gavage) during the gestational period. Analysis of biometric, reproductive performance and embryo-fetal development parameters related to control presented no significant differences, suggesting no maternal or embryo-fetal toxicity. Head me...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
CONCLUSIONS: This prospective population-based study represents the largest Brazilian cohort study of ZIKV in pregnancy. Congenital anomalies potentially associated with CZS are less frequent than previously thought. There is a strong relationship between the gestational age of infection (≤11 weeks) and worse early infant prognosis. A notable proportion of apparently asymptomatic newborns can present with subclinical findings within three months of age. PMID: 32920998 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Tags: BJOG Source Type: research
Zika virus (ZIKV) infection during pregnancy has severe consequences on the new-born. The World Health Organization declared the Zika outbreak to be a Public Health Emergency of International Concern (PHEIC) i...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
This study aimed to explore views, perceptions and attitudes towards ZIKV among migrant women from Central and South America, diagnosed with ZIKV infection during pregnancy, and to comprehend healthcare professionals’ perceptions of ZIKV. An exploratory qualitative study, based on phenomenology and grounded theory, was conducted in Barcelona, Spain. Data were collected through in-depth and paired interviews with women diagnosed with ZIKV infection during pregnancy, and semi-structured interviews with healthcare professionals. Women showed good level of awareness of ZIKV, despite some knowledge gaps. The most cons...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
[Mental health from the perspective of women affected by the Zika virus: an ethnographic study in Pará State, Brazil]. Cad Saude Publica. 2020;36(8):e00100019 Authors: Silva DAD, Silva ÉQ Abstract The current study reflects on the Zika virus outbreak that struck the Brazilian population, with both physical and emotional aspects for all those affected. There is a particular group that has to deal on a daily basis with all the difficulties imposed by this new reality: women. The basic assumption of this approach is the need to learn about, understand, and grasp these biopsychosocial issues...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
CONCLUSION: religiosity and religious beliefs were determinant factors in the women's decision to continue their pregnancies. It becomes necessary to continue investigating this theme to understand their experiences and to generate follow-up and support actions from nursing care. PMID: 32876288 [PubMed - in process]
Source: Revista Latino-Americana de Enfermagem - Category: Nursing Authors: Tags: Rev Lat Am Enfermagem Source Type: research
In conclusion, our findings confirm that OPD is a feature of Congenital Zika Syndrome that primarily occurs in children with microcephaly and provide support for policies in which children are referred for rehabilitation with an OPD diagnosis based on caregiver report.
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
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