GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling

Cells often concentrate limited amounts of enzymes at specific subcellular regions for distinct functions. Zhu et  al. show that the small GTPase regulatory enzymes GIT and PIX autonomously form phase-separated condensates without the need for scaffolding molecules. GIT/PIX condensates are modular and positioned at specific cellular compartments for distinct signaling.

Source: Molecular Cell - August 9, 2020 Category: Cytology Authors: Jinwei Zhu, Qingqing Zhou, Yitian Xia, Lin Lin, Jianchao Li, Mengjuan Peng, Rongguang Zhang, Mingjie Zhang Tags: Article Source Type: research