Characteristics of Dolutegravir and Bictegravir Plasma Protein Binding: A First Approach for the Study of Pharmacologic Sanctuaries.

This study aimed to characterize in vitro dolutegravir (DTG) and bictegravir (BIC) binding. They had a preferential binding to human serum albumin (HSA) with two classes of albumin sites. Human alpha-1-acid glycoprotein (HAAG) binding of DTG and BIC showed an atypical nonlinear binding. The low affinity site on HSA, the main plasma binding protein, suggest that the high protein binding rate should not impair passive diffusion.
PMID: 32868324 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - August 30, 2020 Category: Microbiology Authors: Gelé T, Gouget H, Furlan V, Becker PH, Taburet AM, Lambotte O, Barrail-Tran A Tags: Antimicrob Agents Chemother Source Type: research