MiR-542-5p regulates the progression of diabetic retinopathy by targeting CARM1.

MiR-542-5p regulates the progression of diabetic retinopathy by targeting CARM1. Acta Biochim Pol. 2020 Sep 01;: Authors: Guo N, Nulahou A, Bu Q, Liu M, Wang Y, Zhao Y, Yang L, Gao Y Abstract Diabetic retinopathy (DR), as the most frequent microvascular complication of diabetes mellitus (DM), causes vision loss and blindness in adults worldwide with increasing incidence. MicroRNAs (miRNAs) are involved in the regulation of DR. However, the role of miR-542-5p is still unknown. Here, we demonstrate that miR-542-5p is down-regulated in patients with DR and in high-glucose (HG)-treated retinal pigment epithelial cells. Moreover, miR-542-5p overexpression inhibits apoptosis in retinal pigment epithelial cells exposed to HG. The interaction between miR-542-5p and co-activator-associated arginine methyltransferase 1 (CARM1) is confirmed. MiR-542-5p mimics decrease the CARM1 level and miR-542-5p inhibitor increases the CARM1 level. Additionally, CARM1 overexpression promotes the miR-542-5p-mediated apoptosis in HG-treated retinal pigment epithelial cells. In summary, the data suggest that miR-542-5p may suppress apoptosis in retinal pigment epithelial cells via targeting CARM1, which provides a new therapeutic target for the treatment of patients with DR. PMID: 32870623 [PubMed - as supplied by publisher]
Source: Acta Biochim Pol - Category: Biochemistry Authors: Tags: Acta Biochim Pol Source Type: research

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Alström syndrome (ALMS) is a rare autosomal recessive multi-organ syndrome considered to date as a ciliopathy and caused by variations in ALMS1. Phenotypic variability is well-documented, particularly for the systemic disease manifestations; however, early-onset progressive retinal degeneration affecting both cones and rods (cone-rod type) is universal, leading to blindness by the teenage years. Other features include cardiomyopathy, kidney dysfunction, sensorineural deafness, and childhood obesity associated with hyperinsulinemia and type 2 diabetes mellitus. Here, we present an unusual and delayed retinal dystrophy ...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Authors: Kaštelan S, Orešković I, Bišćan F, Kaštelan H, Gverović Antunica A Abstract Diabetic retinopathy (DR) is one of the most common microvascular complications of diabetes mellitus (DM) and a leading cause of blindness in working-age adults in developed countries. Numerous investigations have recognised inflammation and angiogenesis as important factors in the development of this complication of diabetes. Current methods of DR treatment are predominantly used at advanced stages of the disease and could be associated with serious side effects. Therefore, new diagnostic methods are...
Source: Biochemia Medica - Category: Biochemistry Tags: Biochem Med (Zagreb) Source Type: research
CONCLUSIONS: The cost per patient for treating DR was lower in Hungary than in other countries. Due to the increasing socioeconomic burden of proliferative DR and diabetes-related blindness, it would be important to invest in DR screening, prevention and early treatment. Our new RAAB-based cost of DR model may facilitate comparisons of DR treatment costs across countries. PMID: 32788328 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Authors: Striglia E, Caccioppo A, Castellino N, Reibaldi M, Porta M Abstract INTRODUCTION: Diabetic retinopathy (DR) is one of the main pathological features of the diabetes mellitus spectrum. It is estimated that in 2020 about 4 million people worldwide suffered from blindness or visual impairment caused by DR. Many patients cannot access treatment, mostly because of high costs, while others discontinue it prematurely due to the high number of intravitreal administrations required, or the occurrence of ocular complications, or discomfort in quality of life. AREAS COVERED: The aims of this paper are to summariz...
Source: Expert Opinion on Emerging Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Emerg Drugs Source Type: research
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Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Diabetes mellitus is a highly prevalent disease, associated with chronic microvascular and macrovascular complications, including blindness and cardiovascular disease. Type 2 diabetes mellitus (T2DM) is the most common form, representing approximately 90% of all diagnosed cases [1]. In Spain, the Di@bet.es Study estimated the overall prevalence of diabetes mellitus, adjusted for age and gender, at about 13.8%, nearly half of which was unknown diabetes [2]. In Castilla y Le ón—the largest administrative division in both the country and the European Union as a whole—the results of the RECCyL study show tha...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
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Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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Source: Asia-Pacific Journal of Ophthalmology - Category: Opthalmology Tags: Original Study Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Review Source Type: research
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Source: Diabetologia - Category: Endocrinology Source Type: research
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