Adiponectin treatment improves insulin resistance in mice by regulating the expression of the mitochondrial-derived peptide MOTS-c and its response to exercise via APPL1 –SIRT1–PGC-1α

Conclusions/interpretationOur findings showed that the APPL1 –SIRT1–PGC-1α pathway regulates the production and/or secretion of skeletal muscle MOTS-c by mediating adiponectin signalling. Our study provides an insight into the cellular and molecular pathways underlying the pathogenesis of diabetes and shows that MOTS-c is a potential novel therapeutic ta rget in the treatment of diabetes.Graphical abstract
Source: Diabetologia - Category: Endocrinology Source Type: research