C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?

In conclusion, with evidence pointing to a multiple-hit model, loss-of-function on itself seems to be insufficient to cause neurodegeneration inC9orf72 ALS/FTD.

http://link.springer.com/10.1007/s00401-020-02214-x

Source: Acta Neuropathologica - September 1, 2020 Category: Neurology Source Type: research