Plasmin could be the link between COVID-19 comorbidities and serious illness
(University of Alabama at Birmingham) Why is the COVID-19 virus more dangerous in people with comorbidities? Literature analysis shows that comorbidities like hypertension, diabetes, coronary heart disease, cerebrovascular illness, chronic obstructive pulmonary disease and kidney dysfunction all feature elevated levels of the extracellular protease plasmin. Plasmin is able to nick proteins sequences called furin sites. For many viruses, this nicking increases viral infectivity, including SARS and MERS -- the two virulent coronaviruses that are related to the COVID-19 virus.
Authors: Lam UN, Siddik NSFMM, Yussof SJM, Ilenghoven D, Ibrahim S PMID: 32971604 [PubMed]
Abstract Inhaled pulmonary vasodilators are a powerful tool in the arsenal of therapies designed to treat pulmonary hypertension in pediatrics. Yet only 1 inhaled vasodilator, inhaled nitric oxide (INO), has been approved by the Food and Drug Administration for use in neonates> 34 weeks gestational age with persistent pulmonary hypertension of the newborn. Off-label use of inhaled vasodilators is common in the neonatal and pediatric population despite a lack of evidence. Growing focus on providing evidence-based therapies combined with the increasing cost of INO has led to the exploration of other inhaled pulmo...
In this report, we describe the case of a SARS-CoV-2 infection (COVID-19) in an infant with mild fever and diarrhea in the absence of respiratory distress. A 45-day-old male infant with COVID-19 was transferred to our pediatric department. He had mild fever and diarrhea at admission. Positive-to-negative nasal swab conversion occurred on the 21st day from the onset of symptoms. However, stool swab positivity persisted during the 6-week admission period and for 7 weeks during follow-up at an outpatient clinic after discharge. Negative conversion in a stool specimen occurred on the 142nd day from the onset of symptoms. This ...
In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. PMID: 32975064 [PubMed - in process]
PMID: 32976369 [PubMed - as supplied by publisher]
Authors: Uvais NA, Rasmina V PMID: 32975917 [PubMed - as supplied by publisher]
Conclusions: "Home staying syndrome" is an undefined syndrome of unusual symptoms of abnormal sleep (altering sleep time and duration) and frequent urination> 3 times/hour. This syndrome is associated with staying at home for a long period of time and is easily resolved by doing any activity such as sports or visiting friends. While this syndrome is rare, it may be more prevalent now due to the COVID-19 pandemic, which forces people to stay home for infection prevention. PMID: 32975916 [PubMed - as supplied by publisher]
Abstract Without a nationwide strategy or infrastructure, we've missed a chance to control the pandemic. PMID: 32976142 [PubMed - as supplied by publisher]
Authors: Abstract The pandemic has stretched resources and complicated the delivery of care. PMID: 32976135 [PubMed - as supplied by publisher]
Authors: PMID: 32976133 [PubMed - as supplied by publisher]