Corticotrophin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala.

In this study, we are the first to use fast-scan cyclic voltammetry to classify local electrically-evoked NE release in the CeA and to determine if acute alcohol and CRF modulate it. Evoked NE release is action potential dependent, is abolished after depletion of monoaminergic vesicles, differs pharmacologically from dopamine release, is insensitive to acute alcohol, and decreases in response to locally applied CRF. Taken together, these results indicate that NE release in the CeA is released canonically in a vesicular-dependent manner, and that while acute alcohol does not directly alter NE release, CRF decreases it. Our results suggest that CRF acts locally on NE terminals as negative feedback and potentially prevents hyperactivation of the CRF-norepinephrine stress pathway. PMID: 32871155 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32871155?dopt=Abstract

Source: Neuropharmacology - August 28, 2020 Category: Drugs & Pharmacology Authors: Hedges DM, Yorgason JT, Brundage JN, Wadsworth HA, Williams B, Steffensen SC, Roberto M Tags: Neuropharmacology Source Type: research